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Home / Catalog / Endocrine / Oxytocin
Oxytocin — sealed research vial, 5 mg
Lot PS-4275312 · 99.5% HPLC · 5 mg
Endocrine research compound

Oxytocin

Oxytocin is a cyclic nonapeptide hormone with an intramolecular disulfide bridge between the cysteine residues at positions 1 and 6, forming the six-residue ring that defines the neurohypophyseal peptide family.

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About Oxytocin

Oxytocin is a cyclic nonapeptide hormone with an intramolecular disulfide bridge between the cysteine residues at positions 1 and 6, forming the six-residue ring that defines the neurohypophyseal peptide family.

It was the first polypeptide hormone to be chemically synthesised, work that earned Vincent du Vigneaud the 1955 Nobel Prize in Chemistry, and it remains a standard reference compound in peptide chemistry.

The disulfide bridge is the critical handling consideration. Reducing agents will open the ring and destroy activity, so any buffer containing DTT or beta-mercaptoethanol is incompatible. Its reconstituted shelf life is shorter than most of the catalogue.

Specifications

Compound nameOxytocin
ClassificationEndocrine research compound
CAS number50-56-6
Molecular formulaC43H66N12O12S2
Molecular weight1007.19 g/mol
SequenceCys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide bridge Cys1-Cys6)
Purity (this lot)99.5% by RP-HPLC
Endotoxin<0.5 EU/mg by LAL
AppearanceWhite lyophilized powder
Vial size5 mg
SolubilityFreely soluble in water
StorageLyophilized: -20 C, desiccated. Reconstituted: 2-8 C, use within 14 days.
Released lotPS-4275312

Handling & storage

Vials arrive lyophilized and sealed under nitrogen. Bring the vial fully to room temperature before breaking the seal — opening a cold vial condenses atmospheric moisture onto the cake.

Direct diluent gently against the inside wall of the vial rather than onto the cake, and allow the material to dissolve without agitation. Vortexing shears longer sequences and introduces air.

Lyophilized: -20 C, desiccated. Reconstituted: 2-8 C, use within 14 days.

A full walkthrough is in the reconstitution guide, and the calculator will work out concentration and draw volume for this vial size.

Laboratory handling

Standard laboratory practice applies: appropriate personal protective equipment, no consumption, no administration to humans or animals, and disposal in accordance with institutional protocol and local regulation.

Documentation

Both certificates below were generated against this specific lot and published before it was released to stock. Enter the lot number in the certificate lookup to retrieve them at any time. New to reading these? See how to read a certificate of analysis.

PS-4275312-P
RP-HPLC purity report · Oxytocin 5 mg
99.5%
PS-4275312-E
LAL bacterial endotoxin assay · Oxytocin 5 mg
<0.5 EU/mg
PS-4275312-MS
Mass-spec identity confirmation · available on request
1007.19

Frequently asked

Why is the reconstituted shelf life shorter than other peptides?

The disulfide bridge is susceptible to reduction and to disulfide scrambling in solution over time.

Which buffers should be avoided?

Anything containing a reducing agent - DTT, beta-mercaptoethanol, TCEP - will open the ring.

How does it differ from vasopressin?

They share the cyclic scaffold but differ at positions 3 and 8, which is what separates their receptor selectivity.

Terms of supply

Oxytocin is supplied for in-vitro laboratory research only. It is not a drug, dietary supplement, food or cosmetic, is not approved by the FDA for any use in humans or animals, and no dosing guidance is published for it. Nothing on this page is a therapeutic, structure–function or health claim. Purchasers must be 21 or over and are responsible for compliance with all applicable law. Full terms of supply.

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