Research use only — not for human or veterinary consumptionEvery lot HPLC-assayed before releaseLAL endotoxin report published per lotCold-packed dispatch, next business dayCertificates searchable by lot number21+ · verified laboratory purchasers only Research use only — not for human or veterinary consumptionEvery lot HPLC-assayed before releaseLAL endotoxin report published per lotCold-packed dispatch, next business dayCertificates searchable by lot number21+ · verified laboratory purchasers only
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L-Glutathione — sealed research vial, 500 mg
Lot PS-3871218 · 99.0% HPLC · 500 mg
Cellular research compound

L-Glutathione

L-Glutathione is a tripeptide with an unusual structural feature: the bond between glutamate and cysteine is a gamma-peptide linkage through the glutamate side-chain carboxyl rather than the standard alpha-peptide bond.

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About L-Glutathione

L-Glutathione is a tripeptide with an unusual structural feature: the bond between glutamate and cysteine is a gamma-peptide linkage through the glutamate side-chain carboxyl rather than the standard alpha-peptide bond.

That gamma linkage is why glutathione resists the peptidases that cleave ordinary tripeptides, and it is the reason the molecule persists intracellularly at millimolar concentrations.

The free cysteine thiol oxidises readily in air to the disulfide dimer GSSG. Solutions should be prepared immediately before use and vials kept tightly sealed; a lot assay confirms the reduced-to-oxidised ratio at release.

Specifications

Compound nameL-Glutathione
ClassificationCellular research compound
CAS number70-18-8
Molecular formulaC10H17N3O6S
Molecular weight307.32 g/mol
Sequencegamma-Glu-Cys-Gly
Purity (this lot)99.0% by RP-HPLC
Endotoxin<0.5 EU/mg by LAL
AppearanceWhite crystalline powder
Vial size500 mg
SolubilityFreely soluble in water
StorageLyophilized: -20 C, tightly sealed. Reconstituted: 2-8 C, use within 14 days.
Released lotPS-3871218

Handling & storage

Vials arrive lyophilized and sealed under nitrogen. Bring the vial fully to room temperature before breaking the seal — opening a cold vial condenses atmospheric moisture onto the cake.

Direct diluent gently against the inside wall of the vial rather than onto the cake, and allow the material to dissolve without agitation. Vortexing shears longer sequences and introduces air.

Lyophilized: -20 C, tightly sealed. Reconstituted: 2-8 C, use within 14 days.

A full walkthrough is in the reconstitution guide, and the calculator will work out concentration and draw volume for this vial size.

Laboratory handling

Standard laboratory practice applies: appropriate personal protective equipment, no consumption, no administration to humans or animals, and disposal in accordance with institutional protocol and local regulation.

Documentation

Both certificates below were generated against this specific lot and published before it was released to stock. Enter the lot number in the certificate lookup to retrieve them at any time. New to reading these? See how to read a certificate of analysis.

PS-3871218-P
RP-HPLC purity report · L-Glutathione 500 mg
99.0%
PS-3871218-E
LAL bacterial endotoxin assay · L-Glutathione 500 mg
<0.5 EU/mg
PS-3871218-MS
Mass-spec identity confirmation · available on request
307.32

Frequently asked

What is a gamma-peptide bond?

A linkage through the glutamate side-chain carboxyl rather than its alpha-carboxyl. It makes the molecule resistant to standard peptidases.

Why does it oxidise so easily?

The free cysteine thiol converts to the GSSG disulfide dimer on air exposure. Keep vials sealed and prepare solutions fresh.

Is the reduced-to-oxidised ratio documented?

Yes - it is confirmed as part of the lot release assay.

Terms of supply

L-Glutathione is supplied for in-vitro laboratory research only. It is not a drug, dietary supplement, food or cosmetic, is not approved by the FDA for any use in humans or animals, and no dosing guidance is published for it. Nothing on this page is a therapeutic, structure–function or health claim. Purchasers must be 21 or over and are responsible for compliance with all applicable law. Full terms of supply.

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