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PeptideSeed supplies research compounds for in-vitro laboratory use only. By entering this site you confirm:
Research use only. Not for human or veterinary consumption. Full terms of supply
L-Glutathione is a tripeptide with an unusual structural feature: the bond between glutamate and cysteine is a gamma-peptide linkage through the glutamate side-chain carboxyl rather than the standard alpha-peptide bond.
L-Glutathione is a tripeptide with an unusual structural feature: the bond between glutamate and cysteine is a gamma-peptide linkage through the glutamate side-chain carboxyl rather than the standard alpha-peptide bond.
That gamma linkage is why glutathione resists the peptidases that cleave ordinary tripeptides, and it is the reason the molecule persists intracellularly at millimolar concentrations.
The free cysteine thiol oxidises readily in air to the disulfide dimer GSSG. Solutions should be prepared immediately before use and vials kept tightly sealed; a lot assay confirms the reduced-to-oxidised ratio at release.
| Compound name | L-Glutathione |
| Classification | Cellular research compound |
| CAS number | 70-18-8 |
| Molecular formula | C10H17N3O6S |
| Molecular weight | 307.32 g/mol |
| Sequence | gamma-Glu-Cys-Gly |
| Purity (this lot) | Pending — per-lot certificate not yet available |
| Endotoxin (this lot) | Pending — per-lot certificate not yet available |
| Appearance | White crystalline powder |
| Vial size | 500 mg |
| Solubility | Freely soluble in water |
| Storage | Lyophilized: -20 C, tightly sealed. Reconstituted: 2-8 C, use within 14 days. |
| Released lot | PS-3871218 |
Vials arrive lyophilized and sealed under nitrogen. Bring the vial fully to room temperature before breaking the seal — opening a cold vial condenses atmospheric moisture onto the cake.
Direct diluent gently against the inside wall of the vial rather than onto the cake, and allow the material to dissolve without agitation. Vortexing shears longer sequences and introduces air.
Lyophilized: -20 C, tightly sealed. Reconstituted: 2-8 C, use within 14 days.
A full walkthrough is in the reconstitution guide, and the calculator will work out concentration and draw volume for this vial size.
Standard laboratory practice applies: appropriate personal protective equipment, no consumption, no administration to humans or animals, and disposal in accordance with institutional protocol and local regulation.
Per-lot laboratory certificate: pending. A reverse-phase HPLC purity report, an LAL bacterial endotoxin assay and a mass-spec identity confirmation for lot PS-3871218 have not been generated or published. PeptideSeed is working directly with its supplier to obtain genuine per-lot documentation and will publish it here, tied to this exact lot number, once it exists. New to reading these? See how to read a certificate of analysis.
A linkage through the glutamate side-chain carboxyl rather than its alpha-carboxyl. It makes the molecule resistant to standard peptidases.
The free cysteine thiol converts to the GSSG disulfide dimer on air exposure. Keep vials sealed and prepare solutions fresh.
Yes - it is confirmed as part of the lot release assay.
L-Glutathione is supplied for in-vitro laboratory research only. It is not a drug, dietary supplement, food or cosmetic, is not approved by the FDA for any use in humans or animals, and no dosing guidance is published for it. Nothing on this page is a therapeutic, structure–function or health claim. Purchasers must be 21 or over and are responsible for compliance with all applicable law. Full terms of supply.
