Metabolic
AOD-9604
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MOTS-c is a 16-residue peptide encoded not in the nuclear genome but in mitochondrial DNA - specifically within the 12S rRNA region. It belongs to the small class of mitochondrial-derived peptides identified since 2015.
MOTS-c is a 16-residue peptide encoded not in the nuclear genome but in mitochondrial DNA - specifically within the 12S rRNA region. It belongs to the small class of mitochondrial-derived peptides identified since 2015.
Its genomic origin is the reason it appears so frequently in mitochondrial biology work: it is one of the few characterised peptides whose coding sequence sits inside the mitochondrial genome itself.
The sequence carries two methionine residues and one tryptophan, making it both oxidation- and light-sensitive. Keep vials sealed, desiccated and in opaque packaging.
| Compound name | MOTS-c |
| Classification | Metabolic research compound |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Purity (this lot) | 99.5% by RP-HPLC |
| Endotoxin | <0.5 EU/mg by LAL |
| Appearance | White lyophilized powder |
| Vial size | 10 mg |
| Solubility | Soluble in sterile water |
| Storage | Lyophilized: -20 C, desiccated, protected from light. Reconstituted: 2-8 C, use within 30 days. |
| Released lot | PS-6963679 |
Vials arrive lyophilized and sealed under nitrogen. Bring the vial fully to room temperature before breaking the seal — opening a cold vial condenses atmospheric moisture onto the cake.
Direct diluent gently against the inside wall of the vial rather than onto the cake, and allow the material to dissolve without agitation. Vortexing shears longer sequences and introduces air.
Lyophilized: -20 C, desiccated, protected from light. Reconstituted: 2-8 C, use within 30 days.
A full walkthrough is in the reconstitution guide, and the calculator will work out concentration and draw volume for this vial size.
Standard laboratory practice applies: appropriate personal protective equipment, no consumption, no administration to humans or animals, and disposal in accordance with institutional protocol and local regulation.
Both certificates below were generated against this specific lot and published before it was released to stock. Enter the lot number in the certificate lookup to retrieve them at any time. New to reading these? See how to read a certificate of analysis.
Its coding sequence sits within mitochondrial DNA - in the 12S rRNA region - rather than in the nuclear genome.
2015, as part of a small group of mitochondrial-derived peptides characterised over the last decade.
Two methionine residues oxidise readily and one tryptophan is photo-labile.
MOTS-c is supplied for in-vitro laboratory research only. It is not a drug, dietary supplement, food or cosmetic, is not approved by the FDA for any use in humans or animals, and no dosing guidance is published for it. Nothing on this page is a therapeutic, structure–function or health claim. Purchasers must be 21 or over and are responsible for compliance with all applicable law. Full terms of supply.
