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Home / Catalog / Specialty / Melanotan II
Melanotan II — sealed research vial, 10 mg
Lot PS-7423137 · 99.0% HPLC · 10 mg
Specialty research compound

Melanotan II

Melanotan II is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone, closed by a lactam bridge between the aspartate and lysine side chains.

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In stock · lot PS-7423137
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About Melanotan II

Melanotan II is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone, closed by a lactam bridge between the aspartate and lysine side chains.

It is a non-selective melanocortin receptor agonist, active across several receptor subtypes - which distinguishes it from PT-141, its C-terminal free-acid metabolite, which shows a different subtype selectivity profile.

The tryptophan residue and the conjugated ring system make it among the more light-sensitive items in the catalogue. Keep vials in opaque packaging throughout handling.

Specifications

Compound nameMelanotan II
ClassificationSpecialty research compound
CAS number121062-08-6
Molecular formulaC50H69N15O9
Molecular weight1024.18 g/mol
SequenceAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Purity (this lot)99.0% by RP-HPLC
Endotoxin<0.5 EU/mg by LAL
AppearanceWhite to off-white lyophilized powder
Vial size10 mg
SolubilitySoluble in sterile water
StorageLyophilized: -20 C, desiccated, protected from light. Reconstituted: 2-8 C, use within 30 days.
Released lotPS-7423137

Handling & storage

Vials arrive lyophilized and sealed under nitrogen. Bring the vial fully to room temperature before breaking the seal — opening a cold vial condenses atmospheric moisture onto the cake.

Direct diluent gently against the inside wall of the vial rather than onto the cake, and allow the material to dissolve without agitation. Vortexing shears longer sequences and introduces air.

Lyophilized: -20 C, desiccated, protected from light. Reconstituted: 2-8 C, use within 30 days.

A full walkthrough is in the reconstitution guide, and the calculator will work out concentration and draw volume for this vial size.

Laboratory handling

Standard laboratory practice applies: appropriate personal protective equipment, no consumption, no administration to humans or animals, and disposal in accordance with institutional protocol and local regulation.

Documentation

Both certificates below were generated against this specific lot and published before it was released to stock. Enter the lot number in the certificate lookup to retrieve them at any time. New to reading these? See how to read a certificate of analysis.

PS-7423137-P
RP-HPLC purity report · Melanotan II 10 mg
99.0%
PS-7423137-E
LAL bacterial endotoxin assay · Melanotan II 10 mg
<0.5 EU/mg
PS-7423137-MS
Mass-spec identity confirmation · available on request
1024.18

Frequently asked

How does it differ from PT-141?

Melanotan II is C-terminally amidated; PT-141 carries a free acid. That changes melanocortin receptor subtype selectivity.

What is the lactam bridge?

A covalent link between the aspartate and lysine side chains that closes the peptide into a ring.

How light-sensitive is it?

Among the most in the catalogue. Keep it in opaque secondary packaging at all times.

Terms of supply

Melanotan II is supplied for in-vitro laboratory research only. It is not a drug, dietary supplement, food or cosmetic, is not approved by the FDA for any use in humans or animals, and no dosing guidance is published for it. Nothing on this page is a therapeutic, structure–function or health claim. Purchasers must be 21 or over and are responsible for compliance with all applicable law. Full terms of supply.

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