Metabolic
MOTS-c
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AOD-9604 is a synthetic 16-residue analogue of the C-terminal fragment of human growth hormone, corresponding to residues 177-191 with an additional N-terminal tyrosine.
AOD-9604 is a synthetic 16-residue analogue of the C-terminal fragment of human growth hormone, corresponding to residues 177-191 with an additional N-terminal tyrosine.
It retains the intramolecular disulfide bridge of the parent fragment, between the cysteine residues at positions 7 and 14, and that bridge is essential to the molecule's conformation.
As with all disulfide-containing sequences in the catalogue, reducing agents are incompatible - DTT, TCEP and beta-mercaptoethanol will open the ring and destroy the structure.
| Compound name | AOD-9604 |
| Classification | Metabolic research compound |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Molecular weight | 1815.08 g/mol |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide Cys7-Cys14) |
| Purity (this lot) | 99.3% by RP-HPLC |
| Endotoxin | <0.5 EU/mg by LAL |
| Appearance | White lyophilized powder |
| Vial size | 5 mg |
| Solubility | Soluble in sterile water |
| Storage | Lyophilized: -20 C, desiccated. Reconstituted: 2-8 C, use within 30 days. |
| Released lot | PS-4602824 |
Vials arrive lyophilized and sealed under nitrogen. Bring the vial fully to room temperature before breaking the seal — opening a cold vial condenses atmospheric moisture onto the cake.
Direct diluent gently against the inside wall of the vial rather than onto the cake, and allow the material to dissolve without agitation. Vortexing shears longer sequences and introduces air.
Lyophilized: -20 C, desiccated. Reconstituted: 2-8 C, use within 30 days.
A full walkthrough is in the reconstitution guide, and the calculator will work out concentration and draw volume for this vial size.
Standard laboratory practice applies: appropriate personal protective equipment, no consumption, no administration to humans or animals, and disposal in accordance with institutional protocol and local regulation.
Both certificates below were generated against this specific lot and published before it was released to stock. Enter the lot number in the certificate lookup to retrieve them at any time. New to reading these? See how to read a certificate of analysis.
Residues 177-191 of the C-terminal region, plus an added N-terminal tyrosine.
Yes, between Cys7 and Cys14. Avoid all reducing agents.
5 mg is the standard bench format for this sequence.
AOD-9604 is supplied for in-vitro laboratory research only. It is not a drug, dietary supplement, food or cosmetic, is not approved by the FDA for any use in humans or animals, and no dosing guidance is published for it. Nothing on this page is a therapeutic, structure–function or health claim. Purchasers must be 21 or over and are responsible for compliance with all applicable law. Full terms of supply.
